Mouse Stk11 activation kit by CRISPRa

CAT#: GA204139

Stk11 CRISPRa kit - CRISPR gene activation of mouse serine/threonine kinase 11

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Stk11
• Locus ID: 20869
• Kit Components:

  GA204139G1, Stk11 gRNA vector 1 in pCas-Guide-CRISPRa

  GA204139G2, Stk11 gRNA vector 2 in pCas-Guide-CRISPRa

  GA204139G3, Stk11 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001301853, NM_001301854, NM_011492, NR_126043
• Synonyms: AA408040; Lkb1; Par-4; R75140
• Summary: This gene encodes a member of the serine/threonine kinase family. The encoded protein, a known tumor suppressor, activates (via phosphorylation) adenine monophosphate-activated protein kinase (AMPK) and AMPK-related kinase proteins. This upstream regulation of the AMPK pathway is thought to regulate a number of different processes, including cell metabolism, cell polarity, apoptosis and DNA damage response. Mutations in a similar gene in human have been associated with Peutz-Jeghers syndrome. Alternative splicing results in multiple transcript variants, including the S isoform which plays a potential role in spermiogenesis. [provided by RefSeq, Sep 2014]