Mouse Tgfbr1 activation kit by CRISPRa

CAT#: GA204323

Tgfbr1 CRISPRa kit - CRISPR gene activation of mouse transforming growth factor, beta receptor I

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Tgfbr1
• Locus ID: 21812
• Kit Components:

  GA204323G1, Tgfbr1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA204323G2, Tgfbr1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA204323G3, Tgfbr1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001312868, NM_001312869, NM_009370
• Synonyms: Alk-5; ALK5; AU017191; ESK2; TbetaR-I; TbetaRI; TGFR-1
• Summary: This gene encodes a member of the transforming growth factor beta (TGF-beta) receptor family of proteins. These proteins comprise one component of the TGF-beta signaling pathway, which transduces extracellular signals into gene expression changes to regulate a wide range of cellular responses, including proliferation, migration, differentiation and apoptosis. Homozygous knockout mice for this gene exhibit impaired angiogenesis and embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]