Mouse Tpm2 activation kit by CRISPRa

CAT#: GA204425

Tpm2 CRISPRa kit - CRISPR gene activation of mouse tropomyosin 2, beta

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Tpm2
• Locus ID: 22004
• Kit Components:

  GA204425G1, Tpm2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA204425G2, Tpm2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA204425G3, Tpm2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001277875, NM_001277876, NM_009416
• Synonyms: Tpm-2; Trop-2
• Summary: This gene belongs to the tropomyosin family which encodes proteins that bind to actin filaments and stabilize them by regulating access to actin modifying proteins. The encoded protein is a high molecular weight tropomyosin expressed in slow skeletal muscle. In humans, mutations in this gene are associated with nemaline myopathy, cap disease and distal arthrogryposis syndromes. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]