Mouse Adamts8 activation kit by CRISPRa

CAT#: GA205270

Adamts8 CRISPRa kit - CRISPR gene activation of mouse a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Adamts8
• Locus ID: 30806
• Kit Components:

  GA205270G1, Adamts8 gRNA vector 1 in pCas-Guide-CRISPRa

  GA205270G2, Adamts8 gRNA vector 2 in pCas-Guide-CRISPRa

  GA205270G3, Adamts8 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001326292, NM_013906
• Synonyms: METH-2; METH2
• Summary: This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. This gene is expressed in mouse lung, heart and macrophage-rich areas of atherosclerotic plaques. The encoded preproprotein undergoes proteolytic processing to generate an active, zinc-dependent aggrecanase enzyme. This gene is located adjacent to a related ADAMTS gene on chromosome 9. [provided by RefSeq, May 2016]