Mouse Cntnap1 activation kit by CRISPRa

CAT#: GA205547

Cntnap1 CRISPRa kit - CRISPR gene activation of mouse contactin associated protein-like 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Cntnap1
• Locus ID: 53321
• Kit Components:

  GA205547G1, Cntnap1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA205547G2, Cntnap1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA205547G3, Cntnap1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_016782
• Synonyms: AI841080; Caspr; NCP1; Nrxn4; p190; shm
• Summary: Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells. Mice that lack CNTAP1 exhibit tremor, ataxia, and significant motor paresis. Normal paranodal junctions fail to form, and the organization of the paranodal loops is disrupted. Contactin is undetectable in the paranodes, and potassium channels are displaced from the juxtaparanodal into the paranodal domains. Also results in a severe decrease in peripheral nerve conduction velocity. [UniProtKB/Swiss-Prot Function]