Mouse Crbn activation kit by CRISPRa

CAT#: GA206297

Crbn CRISPRa kit - CRISPR gene activation of mouse cereblon

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Crbn
• Locus ID: 58799
• Kit Components:

  GA206297G1, Crbn gRNA vector 1 in pCas-Guide-CRISPRa

  GA206297G2, Crbn gRNA vector 2 in pCas-Guide-CRISPRa

  GA206297G3, Crbn gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_021449, NM_175357
• Synonyms: 2610203G15Rik; 2900045O07Rik; AF229032; AW108261; piL
• Summary: This gene encodes a protein with a Lon protease domain, a "regulators of G protein-signaling" (RGS)-like domain and a leucine zipper. It has been proposed to regulate the assembly and surface expression of large-conductance calcium-activated potassium channels in brain and to bind thalidomide. In humans mutation in this gene causes autosomal recessive nonsyndromic cognitive disability. In mouse deficiency of this gene serves as a model to study the molecular mechanisms governing learning and memory as they relate to intellectual disability. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]