Mouse Ndufa7 activation kit by CRISPRa

CAT#: GA206767

Ndufa7 CRISPRa kit - CRISPR gene activation of mouse NADH:ubiquinone oxidoreductase subunit A7

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Ndufa7
• Locus ID: 66416
• Kit Components:

  GA206767G1, Ndufa7 gRNA vector 1 in pCas-Guide-CRISPRa

  GA206767G2, Ndufa7 gRNA vector 2 in pCas-Guide-CRISPRa

  GA206767G3, Ndufa7 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_023202, NR_103514, NR_103515, NR_103516
• Synonyms: 14.5kDa; 2400007M02Rik; CI-B14.5a
• Summary: This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes the transfer of electrons from NADH to the electron acceptor ubiquinone. The proton gradient created by electron transfer drives the conversion of ADP to ATP. Complex I has been biochemically separated into four fractions. The bovine ortholog of this protein has been reported to be part of the I-lambda fraction, which forms the extrinsic globular domain. In humans, deficiencies in complex I are associated with myopathies, encephalomyopathies, and neurodegenerative disorders. Pseudogenes of this gene are located on chromosomes 7 and 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]