Mouse Ccnh activation kit by CRISPRa

CAT#: GA206898

Ccnh CRISPRa kit - CRISPR gene activation of mouse cyclin H

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Ccnh
• Locus ID: 66671
• Kit Components:

  GA206898G1, Ccnh gRNA vector 1 in pCas-Guide-CRISPRa

  GA206898G2, Ccnh gRNA vector 2 in pCas-Guide-CRISPRa

  GA206898G3, Ccnh gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001347587, NM_001347588, NM_023243
• Synonyms: 6330408H09Rik; AI661354; AV102684; AW538719
• Summary: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. [UniProtKB/Swiss-Prot Function]