Mouse Eloc activation kit by CRISPRa

CAT#: GA207589

Eloc CRISPRa kit - CRISPR gene activation of mouse elongin C

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Eloc
• Locus ID: 67923
• Kit Components:

  GA207589G1, Eloc gRNA vector 1 in pCas-Guide-CRISPRa

  GA207589G2, Eloc gRNA vector 2 in pCas-Guide-CRISPRa

  GA207589G3, Eloc gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001310470, NM_026456
• Synonyms: 2610043E24Rik; 2610301I15Rik; AA407206; AI987979; AW049146; Tceb1
• Summary: The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes. [UniProtKB/Swiss-Prot Function]