Mouse Rab43 activation kit by CRISPRa

CAT#: GA208341

Rab43 CRISPRa kit - CRISPR gene activation of mouse RAB43, member RAS oncogene family

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Rab43
• Locus ID: 69834
• Kit Components:

  GA208341G1, Rab43 gRNA vector 1 in pCas-Guide-CRISPRa

  GA208341G2, Rab43 gRNA vector 2 in pCas-Guide-CRISPRa

  GA208341G3, Rab43 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001039394, NM_133717, NR_104477, NR_104478
• Synonyms: 1810048P08Rik; 2500004H21Rik; AW490415
• Summary: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. [UniProtKB/Swiss-Prot Function]