Mouse Aldh6a1 activation kit by CRISPRa

CAT#: GA211834

Aldh6a1 CRISPRa kit - CRISPR gene activation of mouse aldehyde dehydrogenase family 6, subfamily A1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Aldh6a1
• Locus ID: 104776
• Kit Components:

  GA211834G1, Aldh6a1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA211834G2, Aldh6a1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA211834G3, Aldh6a1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001313967, NM_134042
• Synonyms: 1110038I05Rik; Mmsdh
• Summary: This gene encodes a member of the aldehyde dehydrogenase protein family. The encoded enzyme is a mitochondrial methylmalonate semialdehyde dehydrogenase that plays a role in the valine and pyrimidine catabolic pathways. This enzyme catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Mutations in the human gene result in Methylmalonate Semialdehyde Dehydrogenase Deficiency, characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]