Mouse Dis3l activation kit by CRISPRa

CAT#: GA213164

Dis3l CRISPRa kit - CRISPR gene activation of mouse DIS3 like exosome 3'-5' exoribonuclease

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Dis3l
• Locus ID: 213550
• Kit Components:

  GA213164G1, Dis3l gRNA vector 1 in pCas-Guide-CRISPRa

  GA213164G2, Dis3l gRNA vector 2 in pCas-Guide-CRISPRa

  GA213164G3, Dis3l gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001001295, NM_001177784, NM_172519
• Synonyms: AV340375
• Summary: Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. [UniProtKB/Swiss-Prot Function]