Mouse Cps1 activation kit by CRISPRa

CAT#: GA213914

Cps1 CRISPRa kit - CRISPR gene activation of mouse carbamoyl-phosphate synthetase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Cps1
• Locus ID: 227231
• Kit Components:

  GA213914G1, Cps1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA213914G2, Cps1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA213914G3, Cps1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001080809
• Synonyms: 4732433M03Rik; CPS; D1Ucla3
• Summary: This gene encodes a protein localized to the inner mitochondrial matrix. The encoded protein plays a role in the detoxification of ammonia by catalyzing the first step in the urea cycle in which carbomyl-phosphate is synthesized from ammonia and bicarbonate. Carbamoyl-phosphate is subsequently converted to urea that is excreted by the kidneys. Deficiency of the encoded enzyme leads to an accumulation of ammonia in the blood. High levels of ammonia are toxic to the central nervous system and result in neurological disorders. [provided by RefSeq, Oct 2013]