Mouse Dclre1c activation kit by CRISPRa

CAT#: GA213931

Dclre1c CRISPRa kit - CRISPR gene activation of mouse DNA cross-link repair 1C

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Dclre1c
• Locus ID: 227525
• Kit Components:

  GA213931G1, Dclre1c gRNA vector 1 in pCas-Guide-CRISPRa

  GA213931G2, Dclre1c gRNA vector 2 in pCas-Guide-CRISPRa

  GA213931G3, Dclre1c gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001110214, NM_001302674, NM_001302684, NM_146114, NM_175683, NM_001362903, NM_001362904
• Synonyms: 9930121L06Rik; AI661365; Art; Snm1l
• Summary: This gene encodes a member of the SNM1 family of nucleases and is involved in V(D)J recombination and DNA repair. This protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Homozygous knockout mice for this gene exhibit severe combined immunodeficiency with sensitivity to ionizing radiation. Mutations in this gene in humans can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]