Mouse Smox activation kit by CRISPRa

CAT#: GA214017

Smox CRISPRa kit - CRISPR gene activation of mouse spermine oxidase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Smox
• Locus ID: 228608
• Kit Components:

  GA214017G1, Smox gRNA vector 1 in pCas-Guide-CRISPRa

  GA214017G2, Smox gRNA vector 2 in pCas-Guide-CRISPRa

  GA214017G3, Smox gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001177833, NM_001177834, NM_001177835, NM_001177836, NM_001177837, NM_001177838, NM_001177839, NM_001177840, NM_145533
• Synonyms: B130066H01Rik; PAO; PAOh1; SMO
• Summary: Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal. [UniProtKB/Swiss-Prot Function]