Mouse Adamts12 activation kit by CRISPRa

CAT#: GA214845

Adamts12 CRISPRa kit - CRISPR gene activation of mouse a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Adamts12
• Locus ID: 239337
• Kit Components:

  GA214845G1, Adamts12 gRNA vector 1 in pCas-Guide-CRISPRa

  GA214845G2, Adamts12 gRNA vector 2 in pCas-Guide-CRISPRa

  GA214845G3, Adamts12 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_175501
• Synonyms: ADAMTS-12; AI605170
• Summary: This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active protease. Mice lacking the encoded protein exhibit increased angiogenic response and tumor invasion in different models of angiogenesis and, severe inflammation and delayed recovery when subjected to experimental conditions that induce colitis, endotoxic sepsis and pancreatitis. [provided by RefSeq, Jul 2016]