Mouse Hist2h2be activation kit by CRISPRa

CAT#: GA216247

Hist2h2be CRISPRa kit - CRISPR gene activation of mouse histone cluster 2, H2be

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Hist2h2be
• Locus ID: 319190
• Kit Components:

  GA216247G1, Hist2h2be gRNA vector 1 in pCas-Guide-CRISPRa

  GA216247G2, Hist2h2be gRNA vector 2 in pCas-Guide-CRISPRa

  GA216247G3, Hist2h2be gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_178214
• Synonyms: AV127319; H2b-613; T25626
• Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family, and generates two transcripts through the use of a putative stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Aug 2015]