Mouse Tnfsfm13 activation kit by CRISPRa

CAT#: GA217912

Tnfsfm13 CRISPRa kit - CRISPR gene activation of mouse tumor necrosis factor (ligand) superfamily, membrane-bound member 13

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Tnfsfm13
• Locus ID: 619441
• Kit Components:

  GA217912G1, Tnfsfm13 gRNA vector 1 in pCas-Guide-CRISPRa

  GA217912G2, Tnfsfm13 gRNA vector 2 in pCas-Guide-CRISPRa

  GA217912G3, Tnfsfm13 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001034097, NM_001034098, NM_001159503
• Synonyms: Tnfsf12-Tnfsf13; Tnfsf12Tnfsf13; Tnfsf12tnfsf13; Twe-pril
• Summary: This gene represents read-through transcription between neighboring genes encoding tumor necrosis factor family members. This results a hybrid protein composed of the cytoplasmic and transmembrane domains of family member 12 fused to the C-terminal domain of family member 13. The homologous fusion protein in human is known to be membrane-anchored and presents the receptor-binding domain of family member 13 at the cell surface. It stimulates cycling in T- and B-lymphoma cell lines. Alternative splicing of this mouse gene results in multiple transcript variants. [provided by RefSeq, Oct 2010]