B4GALT7 Human Gene Knockout Kit (CRISPR)
CAT#: KN200258BN
B4GALT7 - human gene knockout kit via CRISPR, HDR mediated
HDR-mediated knockout kit validation
USD 1,290.00
4 Weeks*
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 GFP-puro donor, 1 scramble control |
Donor DNA | mBFP-Neo |
Symbol | B4GALT7 |
Locus ID | 11285 |
Disclaimer | The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_007255 |
Synonyms | EDSP1; XGALT1; XGPT1 |
Summary | This gene is a member of the beta-1,4-galactosyltransferase (beta4GalT) family. Family members encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose. Each beta4GalT member has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus which then remains uncleaved to function as a transmembrane anchor. The enzyme encoded by this gene attaches the first galactose in the common carbohydrate-protein linkage (GlcA-beta1,3-Gal-beta1,3-Gal-beta1,4-Xyl-beta1-O-Ser) found in proteoglycans. This enzyme differs from other beta4GalTs because it lacks the conserved Cys residues found in beta4GalT1-beta4GalT6 and it is located in cis-Golgi instead of trans-Golgi. Mutations in this gene have been associated with the progeroid form of Ehlers-Danlos syndrome. [provided by RefSeq, Oct 2009] |
Documents
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN200258 | B4GALT7 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN200258LP | B4GALT7 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN200258RB | B4GALT7 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN400258 | B4GALT7 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
USD 1,290.00 |
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GA107780 | B4GALT7 CRISPRa kit - CRISPR gene activation of human beta-1,4-galactosyltransferase 7 |
USD 1,290.00 |
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