PDHA1 Human Gene Knockout Kit (CRISPR)
CAT#: KN201831RB
PDHA1 - human gene knockout kit via CRISPR, HDR mediated
HDR-mediated knockout kit validation
USD 1,290.00
4 Weeks*
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 GFP-puro donor, 1 scramble control |
Donor DNA | RFP-BSD |
Symbol | PDHA1 |
Locus ID | 5160 |
Disclaimer | The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_000284, NM_001173454, NM_001173455, NM_001173456 |
Synonyms | PDHA; PDHAD; PDHCE1A; PHE1A |
Summary | 'The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]' |
Documents
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Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN201831 | PDHA1 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN201831BN | PDHA1 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN201831LP | PDHA1 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN401831 | PDHA1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
USD 1,290.00 |
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GA103457 | PDHA1 CRISPRa kit - CRISPR gene activation of human pyruvate dehydrogenase E1 alpha 1 subunit |
USD 1,290.00 |
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