SHP2 (PTPN11) Human Gene Knockout Kit (CRISPR)
CAT#: KN220029RB
PTPN11 - human gene knockout kit via CRISPR, HDR mediated
HDR-mediated knockout kit validation
USD 1,290.00
4 Weeks*
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 GFP-puro donor, 1 scramble control |
Donor DNA | RFP-BSD |
Symbol | SHP2 |
Locus ID | 5781 |
Disclaimer | The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_002834, NM_080601, NM_001330437 |
Synonyms | BPTP3; CFC; JMML; METCDS; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2 |
Summary | 'The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]' |
Documents
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN220029 | PTPN11 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN220029BN | PTPN11 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN220029LP | PTPN11 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN420029 | PTPN11 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
USD 1,290.00 |
|
GA103926 | PTPN11 CRISPRa kit - CRISPR gene activation of human protein tyrosine phosphatase non-receptor type 11 |
USD 1,290.00 |
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