WRN Human Gene Knockout Kit (CRISPR)
CAT#: KN222919RB
WRN - human gene knockout kit via CRISPR, HDR mediated
HDR-mediated knockout kit validation
USD 1,290.00
4 Weeks*
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 GFP-puro donor, 1 scramble control |
Donor DNA | RFP-BSD |
Symbol | WRN |
Locus ID | 7486 |
Disclaimer | The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_000553 |
Synonyms | RECQ3; RECQL2; RECQL3 |
Summary | 'This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017]' |
Documents
Product Manuals |
FAQs |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN222919 | WRN - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN222919BN | WRN - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN222919LP | WRN - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN422919 | WRN - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
USD 1,290.00 |
|
GA105162 | WRN CRISPRa kit - CRISPR gene activation of human WRN RecQ like helicase |
USD 1,290.00 |
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