ODF2 Human Gene Knockout Kit (CRISPR)

CAT#: KN401985

ODF2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.

Product Images

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Specifications

Product Data

• Format: 2 gRNA vectors, 1 linear donor
• Donor DNA: EF1a-GFP-P2A-Puro
• Symbol: ODF2
• Locus ID: 4957
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001242352, NM_001242353, NM_001242354, NM_002540, NM_153432, NM_153433, NM_153435, NM_153436, NM_153437, NM_153439, NM_153440, NR_036754, NR_036755, NR_036756, NR_036757, NM_001351577, NM_001351578, NM_001351579, NM_001351580, NM_001351581, NM_001351582, NM_001351583, NM_001351584, NM_001351585, NM_001351586, NM_001351587, NM_001351588
• Synonyms: CT134; ODF2/1; ODF2/2; ODF84
• Summary: 'The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as 'Cenexins', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers. [provided by RefSeq, Oct 2010]'