GLUD1 Human Gene Knockout Kit (CRISPR)
CAT#: KN411132
GLUD1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.
KN2.0 knockout kit validation
USD 1,290.00
2 Weeks*
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 linear donor |
Donor DNA | EF1a-GFP-P2A-Puro |
Symbol | GLUD1 |
Locus ID | 2746 |
Disclaimer | The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_001318900, NM_001318901, NM_001318902, NM_001318904, NM_001318905, NM_001318906, NM_005271 |
Synonyms | GDH; GDH1; GLUD |
Summary | 'This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X. [provided by RefSeq, Jan 2016]' |
Documents
Product Manuals |
FAQs |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN211132 | GLUD1 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN211132BN | GLUD1 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN211132LP | GLUD1 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN211132RB | GLUD1 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
GA101833 | GLUD1 CRISPRa kit - CRISPR gene activation of human glutamate dehydrogenase 1 |
USD 1,290.00 |
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