Dystrobrevin alpha (DTNA) Human Gene Knockout Kit (CRISPR)

CAT#: KN413549

DTNA - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.

Product Images

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Specifications

Product Data

• Format: 2 gRNA vectors, 1 linear donor
• Donor DNA: EF1a-GFP-P2A-Puro
• Symbol: Dystrobrevin alpha
• Locus ID: 1837
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001128175, NM_001198938, NM_001198939, NM_001198940, NM_001198941, NM_001198942, NM_001198943, NM_001198944, NM_001198945, NM_001390, NM_001391, NM_001392, NM_032975, NM_032978, NM_032979, NM_032980, NM_032981
• Synonyms: D18S892E; DRP3; DTN; DTN-A; LVNC1
• Summary: 'The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]'