Abcb1b Mouse Gene Knockout Kit (CRISPR)
CAT#: KN500614
Abcb1b - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated.
KN2.0 knockout kit validation
USD 1,290.00
2 Weeks*
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 linear donor |
Donor DNA | EF1a-GFP-P2A-Puro |
Symbol | Abcb1b |
Locus ID | 18669 |
Disclaimer | The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_011075 |
Synonyms | Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1 |
Summary | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene encodes a membrane glycoprotein which confers a multidrug-resistance phenotype. The protein encoded by the human gene is an ATP-dependent drug efflux pump for xenobiotic compounds which is responsible for decreased drug accumulation in multidrug-resistant cells and mediates the development of resistance to anticancer drugs. [provided by RefSeq, Jul 2008] |
Documents
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Resources
Other Versions
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KN300614 | Abcb1b - mouse gene knockout kit via CRISPR, HDR mediated |
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KN300614BN | Abcb1b - mouse gene knockout kit via CRISPR, HDR mediated |
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KN300614LP | Abcb1b - mouse gene knockout kit via CRISPR, HDR mediated |
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KN300614RB | Abcb1b - mouse gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
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GA203199 | Abcb1b CRISPRa kit - CRISPR gene activation of mouse ATP-binding cassette, sub-family B (MDR/TAP), member 1B |
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