KRIT1 / CCM1 (His-tag) Human Protein

CAT#: AR26002PU-N

KRIT1 / CCM1 (His-tag) human recombinant protein, 20 µg

Product Images

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  MLLKEAINKPYEKVRIYRMDGSYRSVELKHGNNTTVQQIMEGMRLSQETQQYFTIWICSENLSLQLKPYHKPLQHVRDWPEILAELTNLDPQRETPQLFLRRDVRLPLEVEKQIEDPLAILILFDEARYNLLKGFYTAPDAKLITLASLLLQIVYGNYESKKHKQGFLNEENLKSIVPVTKLKSKAPHWTNRILHEYKNLSTSEGVSKEMHHLQRMFLQNCWEIPTYGAAFFTGQIFTKASPSNHKVIPVYVGVNIKGLHLLNMETKALLISLKYGCFMWQLGDTDTCFQIHSMENKMSFIVHTKQAGLVVKLLMKLNGQLMPTERNSLEHHHHH
• Tag: His-tag
• Predicted MW: 39 kDa
• Purity: >90% by SDS-PAGE and silver stain
• Buffer: Presentation State: Purified
  State: Lyophilized protein
  Buffer System: 30mM NaCl, 50mM NaP, pH 7.4
  Stabilizer: None
• Endotoxin: < 0.1 ng/µg of CCM-1
• Reconstitution: Restore in water or other buffer solutions and stored at -20°C.
• Preparation: Lyophilized protein
• Protein Description: Recombinant Human recombinant CCM-1/Krit1, aa. 718
• Note: Protein RefSeq: NM_004912
  mRNA RefSeq: NM_194456.1
• Storage: Store lyophilized at 2-8°C for 6 months or at -20°C long term.
  After reconstitution store the antibody undiluted at 2-8°C for one month
  or (in aliquots) at -20°C long term.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.

Reference Data

• RefSeq: NP_001013424
• Locus ID: 889
• UniProt ID: O00522
• Cytogenetics: 7q21.2
• Synonyms: CAM; CCM1
• Summary: This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]
• Protein Families: Druggable Genome