Azurocidin Human Protein

CAT#: AR31010PU-N

Human Azurocidin purified from Human Neutrophils.

Specifications

Product Data

• Species: Human
• Expression Host: Neutrophils
• Concentration: lot specific
• Purity: > 95 % by SDS-PAGE
• Buffer: 20mM HEPES-NaOH, pH 8.0 containing 0.4M Sodium Chloride, 0.1mM PMSF, 0.02% Lubrol.
  Preservative: Proprietary formula containing 0.1% preservative, bromo-nitro-dioxane/methylisothiazolone
• Preparation: Liquid purified protein
• Storage: Store the antigen at -20°C.
  Avoid multiple freeze/thaw cycles.
  Shelf life: one year from despatch.

Reference Data

• RefSeq: NP_001691
• Locus ID: 566
• Cytogenetics: 19p13.3
• Synonyms: AZAMP; AZU; CAP37; HBP; hHBP; HUMAZUR; NAZC
• Summary: 'Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. This gene encodes a preproprotein that is proteolytically processed to generate a mature azurophil granule antibiotic protein, with monocyte chemotactic and antimicrobial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, Nov 2015]'
• Protein Families: Druggable Genome, Protease