Natriuretic peptides B (1-32) Human Protein

CAT#: AR31130PU-N

Natriuretic peptides B (1-32) human protein, 0.5 mg

Specifications

Product Data

• Species: Human
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  NH2-SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH-OH
• Predicted MW: 3466.06 Da
• Purity: >95% by HPLC
• Buffer: State: Purified peptide
• Preparation: Purified peptide
• Protein Description: Human Brain natriuretic peptide (1-32).
  Formula: C₁₄₃H₂₂₄N₅₀O₄₂S₄
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: One year from despatch.

Reference Data

• RefSeq: NP_002512
• Locus ID: 4879
• Cytogenetics: 1p36.22
• Synonyms: BNP
• Summary: 'This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Aug 2020]'
• Protein Families: Druggable Genome, Secreted Protein, Stem cell - Pluripotency