Apolipoprotein A I / APO AI

CAT#: BA681

Human Apolipoprotein AI (Apo AI).

Specifications

Product Data

• Species: Human
• Expression Host: Plasma
• Concentration: 1.8 mg/ml (OD280 nm, E1% = 12.2)
• Purity: > 95 % pure by SDS-PAGE (Column Chromatography).
• Buffer: 10 mM NH4HCO3, pH 7.4 containing no preservatives.
• Preparation: Liquid purified fraction.

Reference Data

• RefSeq: NP_000030
• Locus ID: 335
• Cytogenetics: 11q23.3
• Synonyms: apo(a)
• Summary: This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein. [provided by RefSeq, Dec 2015]
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: PPAR signaling pathway