Angiopoietin-2 Human Protein
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Other products for "ANGPT2"
Specifications
Product Data | |
Species | Human |
Expression Host | CHO |
Predicted MW | 60-70 kDa |
Purity | >95% pure by SDS-PAGE and visualised by silver stain |
Buffer | Presentation State: Purified State: Lyophilized protein Buffer System: 10 mM Sodium Phosphate, pH 8.0 Stabilizer: None |
Bioactivity | Biological: Determined by its ability to stimulate tubulogenesis in HUVEC cells using a concentration of 0.2μg/ml. |
Endotoxin | < 0.1 ng per µg of Ang-2 |
Reconstitution | Restore in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C. |
Preparation | Lyophilized protein |
Protein Description | Recombinant Human ANG-2 is a C-terminal Histidine tagged glycoprotein which migrates with an apparent molecular mass of 60 – 70 kDa by SDS-PAGE under reducing conditions. Sequencing analysis shows an N-terminal sequence starting with residue 68 (D) of the ANG-2 precursor protein. |
Storage | Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Reference Data | |
RefSeq | NP_001112359 |
Locus ID | 285 |
UniProt ID | O15123 |
Cytogenetics | 8p23.1 |
Synonyms | AGPT2; ANG2 |
Summary | 'This gene belongs to the angiopoietin family of growth factors. The protein encoded by this gene is an antagonist of angiopoietin 1, and both angiopoietin 1 and angiopoietin 2 are ligands for the endothelial TEK receptor tyrosine kinase. Angiopoietin 2 is upregulated in multiple inflammatory diseases and is implicated in the direct control of inflammation-related signaling pathways. The encoded protein affects angiogenesis during embryogenesis and tumorigenesis, disrupts the vascular remodeling ability of angiopoietin 1, and may induce endothelial cell apoptosis. This gene serves a prognostic biomarker for acute respiratory distress syndrome. [provided by RefSeq, Aug 2020]' |
Protein Families | Druggable Genome, Secreted Protein |
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