CD334 / FGFR4 (Fc Chimera) Human Protein

CAT#: DA3529

CD334 / FGFR4 (Fc Chimera) human recombinant protein, 10 µg


USD 180.00

2 Weeks*

Size
    • 10 ug

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Specifications

Product Data
Species Human
Expression Host Insect
Predicted MW 170 kDa
Purity >90% by SDS-PAGE and visualised by silver stain.
Buffer Presentation State: Purified
State: Lyophilized purifed protein.
Buffer System: PBS withou stabilizers.
Bioactivity Biological: Determined by its ability to inhibit Human FGF basic-dependent proliferation on HUVE cells.
The ED50 for this effect is typically at 15-30 ng/ml.
Endotoxin < 0.1 ng per µg of sFGFR-4.
Reconstitution Restore in PBS or medium to a concentration not lower than 50 µg/ml.
The lyophilized sFGFR-4/Fc is soluble in water and most aqueous buffers.
Preparation Lyophilized purifed protein.
Protein Description Recombinant Human soluble FGFR-4 was fused with the Fc-part of Human IgG1. Human recombinant soluble FGFR-4/Fc is a disulfide-linked heterodimeric protein. In the reduced form the glycosylated subunits of sFGFR-4 alpha/Human Fc chimera display a molecular mass of 80-85 kDa.
Note Centrifuge vials before opening!
Storage Store Lyophilized at -20°C to -70°C.
Reconstituted sFGFR-4/Fc should be stored in working aliquots at -20°C.
Avoid repeated freeze-thaw cycles!
Stability Shelf life: One year from despatch.
Reference Data
RefSeq NP_001278909
Locus ID 2264
UniProt ID P22455, J3KPQ0, B4DVP5
Cytogenetics 5q35.2
Synonyms CD334; JTK2; TKF
Summary 'The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. [provided by RefSeq, Aug 2017]'
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Endocytosis, MAPK signaling pathway, Regulation of actin cytoskeleton

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.