VEGFR-3 / Flt-4 (Fc Chimera) Human Protein

CAT#: DA3536

VEGFR-3 / Flt-4 (Fc Chimera) human recombinant protein, 10 µg

Specifications

Product Data

• Species: Human
• Expression Host: Insect
• Predicted MW: 260 kDa
• Purity: >90% by SDS-PAGE and visualised by silver stain.
• Buffer: Presentation State: Purified
  State: Lyophilized purified protein.
  Buffer System: PBS without stabilizers.
• Bioactivity: Biological: Measured by its ability to bind recombinant Rat VEGF-C in a functional solid phase binding assay.
  Immobilised recombinant Human sVEGFR-3/Fc at 5 µg/ml can bind recombinant Rat VEGF-C in a linear range of 8-500 ng/ml.
• Endotoxin: < 0.1 ng per µg of sVEGFR-3/Fc
• Reconstitution: Restore in PBS or medium to a concentration not lower than 100 µg/ml.
  The lyophilised sVEGFR-3/Fc is soluble in water and most aqueous buffers.
• Preparation: Lyophilized purified protein.
• Protein Description: Recombinant Human soluble Vascular Endothelial Growth Factor Receptor-3 (sVEGFR-3) was fused with the Fc part of human IgG1. The recombinant mature sVEGFR-3/Fc is a disulfide-linked homodimeric protein. The sVEGFR-3/Fc monomers have a mass of approximately 130 kDa. The soluble receptor protein consists of all 7 extracellular domains (Met1-Glu774).
• Note: Centrifuge vials before opening!
• Storage: Store lyophilized at -20°C to -70°C.
  Reconstituted sVEGFR-3/Fc should be stored in working aliquots at -20°C.
  Avoid repeated freeze-thaw cycles!
• Stability: Shelf life: One year from despatch.

Reference Data

• RefSeq: NP_001341918
• Locus ID: 2324
• Cytogenetics: 5q35.3
• Synonyms: FLT-4; FLT41; LMPH1A; LMPHM1; PCL; VEGFR-3; VEGFR3
• Summary: 'This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]'
• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Focal adhesion