CD202b / TEK (Fc Chimera) Human Protein

CAT#: DA3538X

CD202b / TEK (Fc Chimera) human recombinant protein, 0.1 mg


USD 365.00

2 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Species Human
Expression Host Insect
Predicted MW 250 kDa
Purity >90% by SDS-PAGE and visualised by silver stain
Buffer Presentation State: Purified
State: Lyophilized purified protein
Buffer System: PBS without stabilizers
Bioactivity Biological: Measured in a functional ELISA assay.
When TIE-2/Fc is immobilized at 4 μg/mL (100 μl/well), it binds rh Angiopoietin-2 with a linear range of 2-100 ng/ml.
Endotoxin < 0.1 ng per µg sTIE-2/Fc.
Reconstitution Restore in PBS or medium to a concentration not lower than 50 µg/ml.
The lyophilised sTIE-2/Fc is soluble in water and most aqueous buffers.
Preparation Lyophilized purified protein
Protein Description Recombinant Human soluble TIE-2/Tek was fused with the Fc part of Human IgG1. The recombinant mature sTIE-2/Fc is a disulfide-linked homodimeric protein. The sTIE-2/Fc monomers have a mass of approximately 125 kDa. The soluble receptor protein consists of the full extracellular domain (Met1-Val730). 
Result by N-terminal sequencing: AMDLILINSL
Note Centrifuge vials before opening!
Storage Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month 
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Reference Data
RefSeq NP_000450
Locus ID 7010
UniProt ID Q02763, Q59HG2
Cytogenetics 9p21.2
Synonyms CD202B; GLC3E; TIE-2; TIE2; VMCM; VMCM1
Summary 'This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]'
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.