PDGFA (PDGF-AB) Human Protein
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Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Predicted MW | 25.5 kDa |
Purity | >95% > 95%, by SDS-PAGE and visualised by silver stain. |
Buffer | Presentation State: Purified State: Lyophilized purified fraction. |
Bioactivity | Biological: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells is < 1 ng/ml. Specific: > 1 x 10e6 units/mg. |
Endotoxin | < 0.1 ng per ug of PDGF-AB. |
Preparation | Lyophilized purified fraction. |
Protein Description | Recombinant human PDGF-AB is a 25.5 kDa disulfide-linked dimer, consisting of one A chain and one B chains (234 total amino acids). |
Note | Always centrifuge product before opening vial! |
Storage | Store The lyophilized PDGF-AB for one month at room temperature or -20°C. Reconstituted PDGF-AB should be stored in working aliquots at -20°C to -70°C. Avoid repeated freeze-thaw cycles! |
Stability | Shelf life: One year from despatch. |
Reference Data | |
RefSeq | NP_002598 |
Locus ID | 5154 |
UniProt ID | P04085 |
Cytogenetics | 7p22.3 |
Synonyms | PDGF-A; PDGF1 |
Summary | 'This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]' |
Protein Families | Druggable Genome |
Protein Pathways | Cytokine-cytokine receptor interaction, Focal adhesion, Gap junction, Glioma, MAPK signaling pathway, Melanoma, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton |
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