Alpha-Synuclein / SNCA (1-140) Human Protein
Other products for "SNCA"
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
|
Predicted MW | 14.46 kDa |
Purity | >95% |
Buffer | Presentation State: Purified State: Lyophilized from a 0.2 um filtered solution Buffer System: 20 mM Tris-HCl buffer (pH 7.5), 100 mM NaCl, 1mM MgCl2 |
Endotoxin | < 1.0 EU per 1 ug of protein (determined by LAL method) |
Reconstitution | Restore in sterile distilled water to a concentration of 1 mg/ml or less. |
Preparation | Lyophilized from a 0.2 um filtered solution |
Protein Description | Purified human recombinant alpha-Synuclein (amino acids 1-140). |
Storage | Upon receipt, store it immediately at 2-8°C for up to one month. For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch |
Reference Data | |
RefSeq | NP_000336 |
Locus ID | 6622 |
UniProt ID | P37840 |
Cytogenetics | 4q22.1 |
Synonyms | NACP; PARK1; PARK4; PD1 |
Summary | 'Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]' |
Protein Families | Druggable Genome |
Protein Pathways | Alzheimer's disease, Parkinson's disease |
Documents
FAQs |
Resources
Recombinant Protein Resources |
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