Casp3 (NM_009810) Mouse Recombinant Protein
CAT#: TP503736
Purified recombinant protein of Mouse caspase 3 (Casp3), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
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Specifications
Product Data | |
Species | Mouse |
Expression Host | HEK293T |
Expression cDNA Clone or AA Sequence |
A DNA sequence from Mouse cDNA ORF Clone, MR203736, encoding Mouse full-length Casp3.
|
Tag | C-MYC/DDK |
Predicted MW | 31.9 kDa |
Concentration | >50 ug/mL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Storage | Store at -80°C after receiving vials. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_033940 |
Locus ID | 12367 |
UniProt ID | P70677 |
Cytogenetics | 8 26.39 cM |
Refseq Size | 1466 |
Refseq ORF | 831 |
Synonyms | A830040C14Rik; AC-3; CASP-3; Caspase-3; CC3; CPP-32; CPP32; Lice; mldy; SCA-1; Yama |
Summary | This gene encodes a protein that belongs to a highly conserved family of cysteinyl aspartate-specific proteases that function as essential regulators of programmed cell death through apoptosis. Members of this family contain an N-terminal pro-domain and require cleavage at specific aspartate residues to become mature. The protein encoded by this gene belongs to a subgroup of cysteinyl aspartate-specific proteases that are activated by initiator caspases and that perform the proteolytic cleavage of apoptotic target proteins. Mice defective for this gene exhibit a variety of phenotypes including reduced neuronal apoptosis resulting in hyperplasias, hearing loss, attenuated osteogenic differentiation of bone marrow stromal stem cells, and pre- and post-natal lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] |
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