Factor VII (F7) (NM_019616) Human Recombinant Protein

CAT#: TP701041

Purified recombinant protein of Human coagulation factor VII (serum prothrombin conversion accelerator) (F7), with C-terminal His tag, secretory expressed in HEK293 cells, 50ug

Product Images

Specifications

Product Data

• Species: Human
• Expression Host: HEK293
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence from TrueORF clone, RC213143, encoding the region Ala21-Pro447 of F7
• Tag: C-His
• Predicted MW: 48.8 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: PBS,pH7.4,10% glycerol
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_062562
• Locus ID: 2155
• UniProt ID: P08709
• Cytogenetics: 13q34
• Refseq Size: 3078
• Refseq ORF: 1332
• Synonyms: SPCA
• Summary: 'This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]'
• Protein Families: Druggable Genome, Protease
• Protein Pathways: Complement and coagulation cascades