Collagen IV (COL4A3) (NM_000091) Human Recombinant Protein
CAT#: TP701247
Purified recombinant protein of Human collagen, type IV, alpha 3 (Goodpasture antigen) (COL4A3), with C-terminal HIS/DDK tag, expressed in HEK293 cells, 20ug
Other products for "COL4A3"
Specifications
Product Data | |
Species | Human |
Expression Host | HEK293 |
Expression cDNA Clone or AA Sequence |
1 MALWIDRMQL LSCIALSLAL VTNSAGFVFT RHSQTTAIPS CPEGTVPLYS GFSFLFVQGN
61 QRAHGQDLGT LGSCLQRFTT MPFLFCNVND VCNFASRNDY SYWLSTPALM PMNMAPITGR 121 ALEPYISRCT VCEGPAIAIA VHSQTTDIPP CPHGWISLWK GFSFIMFTSA GSEGTGQALA 181 SPGSCLEEFR ASPFLECHGR GTCNYYSNSY SFWLASLNPE RMFRKPIPST VKAGELEKII 241 SRCQVCMKKR GGGGSDYKDD DDKHHHHHHH HHH |
Tag | C-HIS/DDK |
Predicted MW | 27.5 kDa |
Concentration | >50 ug/mL as determined by microplate Bradford method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | PBS, pH7.4, 10% glycerol |
Storage | Store at -80°C after receiving vials. |
Stability | Stable for at least 1 year from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_000082 |
Locus ID | 1285 |
UniProt ID | Q01955 |
Cytogenetics | 2q36.3 |
Refseq Size | 8050 |
Refseq ORF | 5010 |
Synonyms | ATS2; ATS3 |
Summary | Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jun 2010] |
Protein Families | Druggable Genome |
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