ARIH1 (NM_005744) Human Recombinant Protein
CAT#: TP701249
Purified recombinant protein of Human ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila) (ARIH1), (Met1-Gly88, Pro91-End), 20ug
Other products for "ARIH1"
Specifications
Product Data | |
Species | Human |
Expression Host | HEK293 |
Expression cDNA Clone or AA Sequence |
1 MDSDEGYNYE FDEDEECSEE
21 DSGAEEEEDE DDDEPDDDTL 41 DLGEVELVEP GLGVGGERDG 61 LLCGETGGGG GSALGPGGGG 81 GGGGGGGGPG HEQEEDYRYE 101 VLTAEQILQH MVECIREVNE 121 VIQNPATITR ILLSHFNWDK 141 EKLMERYFDG NLEKLFAECH 161 VINPSKKSRT RQMNTRSSAQ 181 DMPCQICYLN YPNSYFTGLE 201 CGHKFCMQCW SEYLTTKIME 221 EGMGQTISCP AHGCDILVDD 241 NTVMRLITDS KVKLKYQHLI 261 TNSFVECNRL LKWCPAPDCH 281 HVVKVQYPDA KPVRCKCGRQ 301 FCFNCGENWH DPVKCKWLKK 321 WIKKCDDDSE TSNWIAANTK 341 ECPKCHVTIE KDGGCNHMVC 361 RNQNCKAEFC WVCLGPWEPH 381 GSAWYNCNRY NEDDAKAARD 401 AQERSRAALQ RYLFYCNRYM 421 NHMQSLRFEH KLYAQVKQKM 441 EEMQQHNMSW IEVQFLKKAV 461 DVLCQCRATL MYTYVFAFYL 481 KKNNQSIIFE NNQADLENAT 501 EVLSGYLERD ISQDSLQDIK 521 QKVQDKYRYC ESRRRVLLQH 541 VHEGYEKDLW EYIED |
Tag | Myc-DDK |
Predicted MW | 63.9 kDa |
Concentration | >50 ug/mL as determined by microplate Bradford method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol |
Storage | Store at -80°C after receiving vials. |
Stability | Stable for at least 1 year from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_005735 |
Locus ID | 25820 |
UniProt ID | Q9Y4X5 |
Cytogenetics | 15q24.1 |
Refseq Size | 2178 |
Refseq ORF | 1671 |
Synonyms | ARI; HARI; HHARI; UBCH7BP |
Summary | E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:15236971, PubMed:21532592, PubMed:24076655, PubMed:27565346, PubMed:23707686). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets (PubMed:27565346). The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2 (PubMed:27565346). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes (PubMed:24076655, PubMed:27565346). Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear (PubMed:25624349). According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest (PubMed:25624349). According to another report EIF4E2 ubiquitination leads to its subsequent degradation (PubMed:14623119). Acts as the ligase involved in ISGylation of EIF4E2 (PubMed:17289916).[UniProtKB/Swiss-Prot Function] |
Protein Families | Druggable Genome |
Documents
FAQs |
SDS |
Resources
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