TL1A (TNFSF15) (NM_005118) Human Recombinant Protein

CAT#: TP720030L

Recombinant protein of human tumor necrosis factor (ligand) superfamily, member 15 (TNFSF15) / isoform 2

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Met1-Leu192
• Tag: tag free
• Predicted MW: 21.9 kDa
• Concentration: lot specific
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.5
• Bioactivity: ED50 is less than 5 µg/ml as determined by the dose-dependent inhibition of the proliferation of HUVEC cells.
• Endotoxin: < 0.1 EU per µg protein as determined by LAL test
• Storage: Store at -80°C.
• Stability: Stable for at least 6 months from date of receipt under proper storage and handling conditions.

Reference Data

• RefSeq: NP_005109
• Locus ID: 9966
• UniProt ID: O95150, A0A0U5JA19
• Cytogenetics: 9q32
• Synonyms: TL1; TL1A; TNLG1B; VEGI; VEGI192A
• Summary: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction