IL31 (NM_001014336) Human Recombinant Protein

CAT#: TP720043L

Recombinant protein of human interleukin 31 (IL31)

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Ser24-Thr164
• Tag: tag free
• Predicted MW: 15.8 kDa
• Concentration: lot specific
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: Lyophilized from a 0.2 um filtered solution of PBS, PH7.4.
• Bioactivity: ED50 is 5 ng/mL as determined by inducing STAT3 activation in U87 MG human glioblastoma/astrocytoma cells.
• Endotoxin: < 0.1 EU per µg protein as determined by LAL test
• Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
• Stability: Stable for at least 6 months from date of receipt under proper storage and handling conditions.

Reference Data

• RefSeq: NP_001014358
• Locus ID: 386653
• UniProt ID: Q6EBC2
• Cytogenetics: 12q24.31
• Synonyms: IL-31
• Summary: IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008]
• Protein Families: Secreted Protein, Transmembrane