Thimet Oligopeptidase (THOP1) (NM_003249) Human Recombinant Protein
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Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
Lys2-Cys689
|
Tag | C-His |
Predicted MW | 79.9 kDa |
Concentration | lot specific |
Purity | >95% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | Supplied as a 0.2 μm filtered solution of 20mM PB, 100mM NaCl, 10% Glycerol, pH 7.0. |
Endotoxin | < 0.1 EU per µg protein as determined by LAL test |
Storage | Store at -80°C. |
Stability | Stable for at least 3 months from date of receipt under proper storage and handling conditions. |
Reference Data | |
RefSeq | NP_003240 |
Locus ID | 7064 |
UniProt ID | P52888 |
Cytogenetics | 19p13.3 |
Synonyms | EP24.15; MEPD_HUMAN; MP78; TOP |
Summary | The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015] |
Protein Families | Druggable Genome, Protease |
Protein Pathways | Renin-angiotensin system |
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