p27 KIP 1 (CDKN1B) (NM_004064) Human Recombinant Protein
CAT#: TP720258
Recombinant protein of human cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B)
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
Met1-Thr198
|
Tag | N-His |
Predicted MW | 24.2 kDa |
Concentration | lot specific |
Purity | >95% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4. |
Endotoxin | < 0.1 EU per µg protein as determined by LAL test |
Storage | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Stability | Stable for at least 6 months from date of receipt under proper storage and handling conditions. |
Reference Data | |
RefSeq | NP_004055 |
Locus ID | 1027 |
UniProt ID | P46527, Q6I9V6 |
Cytogenetics | 12p13.1 |
Synonyms | CDKN4; KIP1; MEN1B; MEN4; P27KIP1 |
Summary | This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014] |
Protein Families | Druggable Genome |
Protein Pathways | Cell cycle, Chronic myeloid leukemia, ErbB signaling pathway, Pathways in cancer, Prostate cancer, Small cell lung cancer |
Documents
FAQs |
SDS |
Resources
Recombinant Protein Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC401318 | CDKN1B HEK293T cell transient overexpression lysate (as WB positive control) |
USD 121.00 |
|
LY401318 | Transient overexpression lysate of cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B) |
USD 396.00 |
|
PH301661 | CDKN1B MS Standard C13 and N15-labeled recombinant protein (NP_004055) |
USD 2,055.00 |
|
TP301661 | Recombinant protein of human cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B) |
USD 823.00 |
|
TP710154 | Recombinant protein of human cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B), full length, with C-terminal DDK tag, expressed in sf9, 20ug |
USD 425.00 |
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