MAN1B1 (NM_016219) Human Recombinant Protein
CAT#: TP720726L
Purified recombinant protein of Human mannosidase, alpha, class 1B, member 1 (MAN1B1)
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Specifications
Product Data | |
Species | Human |
Expression Host | HEK293 |
Expression cDNA Clone or AA Sequence |
Asp106-Ala699
|
Tag | C-His |
Predicted MW | 68.7 kDa |
Purity | >95% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | Supplied as a 0.2 um filtered solution of 50mM TrisHCL, 10mM reduced Glutathione, pH 8.0. |
Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg) |
Storage | Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles. |
Stability | Stable for at least 3 months from date of receipt under proper storage and handling conditions. |
Reference Data | |
RefSeq | NP_057303 |
Locus ID | 11253 |
UniProt ID | Q9UKM7 |
Cytogenetics | 9q34.3 |
Refseq Size | 2787 |
Refseq ORF | 2097 |
Synonyms | ERMAN1; ERManI; MANA-ER; MRT15 |
Summary | This gene encodes an enzyme belonging to the glycosyl hydrolase 47 family. This enzyme functions in N-glycan biosynthesis, and is a class I alpha-1,2-mannosidase that specifically converts Man9GlcNAc to Man8GlcNAc isomer B. It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway. Mutations in this gene cause autosomal-recessive intellectual disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Dec 2011] |
Protein Families | Transmembrane |
Protein Pathways | Metabolic pathways, N-Glycan biosynthesis |
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FAQs |
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