Her2 (ERBB2) Human Recombinant Protein
Other products for "Her2"
Specifications
Product Data | |
Species | Human |
Expression Host | CHO |
Expression cDNA Clone or AA Sequence |
Ser22-Thr652
|
Tag | C-Fc |
Predicted MW | The protein has a predicted molecular weight of 96 kDa and migrates at approximately 125-130 kDa on SDS-PAGE with DTT-reduced conditions. |
Concentration | 25µg size is bottled at 0.2mg/mL concentration. 100 µg size is bottled at lot specific concentration. |
Purity | >90% |
Buffer | 1xPBS buffer, pH7.4 |
Bioactivity | PositiveThe definition of the active protein (purified and biotinylated) is defined as the protein that can bind to its biological receptor/ligand. For conjugated protein, it is defined with its function to bind to the ScFv of the active CAR-transfected cells in flow cytometry test. |
Preparation | Affinity Protein A |
Applications | ELISA |
Storage | An unopened vial can be stored at 4°C for 2 weeks or at -20°C and below for six months. This stock solution should be aliquoted and stored at ≤ -70°C to minimize the freeze/thaw cycles. |
Stability | 6 Months |
Reference Data | |
RefSeq | NP_004439.2 |
Locus ID | 2064 |
UniProt ID | P04626 |
Summary | Human epithelial growth factor receptor 2 (HER2), also named ErbB2/Neu receptor, is a member of the epidermal growth factor receptor (EGFR; also known as ErbB) family of receptor tyrosine kinases. In human, this family are consisted of four members: HER1 (EGFR, ERBB1), HER2 (ERBB2), HER3 (ERBB3) and HER4 (ERBB4). The HER family proteins are type I transmembrane growth factor receptors that function to activate intracellular signaling pathways in response to extracellular signals. Their structure consists of an extracellular ligand binding domain, a transmembrane domain, and an intracellular tyrosine kinase domain. Unlike other members of the family, HER2 lacks ligand binding activity and its signaling function is engaged by its ligand-bound heterodimeric partners. Its expression has a close relationship with various tumors. Its overexpression is found in malignant tumors, such as breast, ovarian, gastric, and colorectal cancers. |
Documents
FAQs |
SDS |
Resources
Recombinant Protein Resources |
{0} Product Review(s)
0 Product Review(s)
Submit review
Be the first one to submit a review
Product Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.