Ccl19 (NM_011888) Mouse Recombinant Protein
CAT#: TP723844
Purified recombinant protein of Mouse chemokine (C-C motif) ligand 19 (Ccl19 / MIP-3beta)
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Specifications
Product Data | |
Species | Mouse |
Expression Host | HEK293 |
Expression cDNA Clone or AA Sequence |
Mouse CCL19, the region of Gly26-Val107-Leu-Glu, from gene Accession# NM_011888.2
|
Tag | Tag Free |
Predicted MW | 9.3 kDa |
Concentration | Protein formulated and vialed at >50 ug/mL in specified buffer |
Purity | >95%, as determined by Coomassie stained SDS-PAGE. |
Buffer | 1 x PBS |
Bioactivity | Bioactivity was measured by its property to chemoattract Baf3-hCCR7 transfectants in a dose dependent manner. |
Endotoxin | Less than 0.01 ng per µg protein as determined by the LAL method |
Storage | Store at -80°C. |
Stability | Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles. |
Reference Data | |
RefSeq | NP_036018 |
Locus ID | 24047 |
UniProt ID | O70460, Q548P0 |
Cytogenetics | 4 A5 |
Refseq Size | 720 |
Refseq ORF | 324 |
Synonyms | CKb11; ELC; exodus-3; MIP3B; Scya19 |
Summary | Strongly chemotactic for naive (L-selectinhi) CD4 T-cells and for CD8 T-cells and weakly attractive for resting B-cells and memory (L-selectinlo) CD4 T-cells. May play a role in promoting encounters between recirculating T-cells and dendritic cells and in the migration of activated B-cells into the T-zone of secondary lymphoid tissues. Binds to chemokine receptor CCR7. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. [UniProtKB/Swiss-Prot Function] |
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