FGF4 (NM_002007) Human Recombinant Protein

CAT#: TP723876

Purified recombinant protein of Human fibroblast growth factor 4 (FGF4)

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Human FGF4, the region of Ser54-Leu206, from gene Accession# NM_002007
• Tag: Tag Free
• Predicted MW: 19.7 kDa
• Concentration: Protein formulated and vialed at >50 ug/mL in specified buffer
• Purity: >95%, as determined by Coomassie stained SDS-PAGE
• Buffer: 1 x PBS
• Bioactivity: The ED50 is 0.2-1 ng/ml, corresponding to a specific activity 1-5 x 106 units/mg, determined by a dose-dependent stimulation of NIH3T3 cell proliferation.
• Endotoxin: Less than 0.01 ng per µg protein as determined by the LAL method
• Storage: Store at -80°C.
• Stability: Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.

Reference Data

• RefSeq: NP_001998
• Locus ID: 2249
• UniProt ID: P08620
• Cytogenetics: 11q13.3
• Refseq Size: 1219
• Refseq ORF: 618
• Synonyms: FGF-4; HBGF-4; HST; HST-1; HSTF-1; HSTF1; K-FGF; KFGF
• Summary: 'The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq, Jul 2008]'
• Protein Families: Adult stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Secreted Protein, Stem cell relevant signaling - Wnt Signaling pathway, Transmembrane
• Protein Pathways: MAPK signaling pathway, Melanoma, Pathways in cancer, Regulation of actin cytoskeleton