PRPK (TP53RK) (NM_033550) Human Recombinant Protein
CAT#: TP760196
Recombinant protein of human TP53 regulating kinase (TP53RK), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Other products for "TP53RK"
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
A DNA sequence encoding human full-length TP53RK
|
Tag | N-His |
Predicted MW | 28 kDa |
Concentration | >50 ug/mL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_291028 |
Locus ID | 112858 |
UniProt ID | Q96S44 |
Cytogenetics | 20q13.12 |
Refseq Size | 3384 |
Refseq ORF | 759 |
Synonyms | BUD32; C20orf64; dJ101A2; GAMOS4; Nori-2; Nori-2p; PRPK |
Summary | Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation. [UniProtKB/Swiss-Prot Function] |
Protein Families | Druggable Genome, Protein Kinase |
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