VRK1 (NM_003384) Human Recombinant Protein
CAT#: TP760293
Recombinant protein of human vaccinia related kinase 1 (VRK1), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Other products for "VRK1"
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
A DNA sequence encoding human full-length VRK1
|
Tag | N-His |
Predicted MW | 45.3 kDa |
Concentration | >50 ug/mL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_003375 |
Locus ID | 7443 |
UniProt ID | Q99986 |
Cytogenetics | 14q32.2 |
Refseq Size | 1720 |
Refseq ORF | 1188 |
Synonyms | PCH1; PCH1A |
Summary | 'This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008]' |
Protein Families | Druggable Genome, Protein Kinase |
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